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KMID : 1147120160220010038
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Journal of the Korean Society of Imaging Informatics in Medicine
2016 Volume.22 No. 1 p.38 ~ p.44
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Analysis of Chemical Structure of the Mixture Containing Indocyanine Green (ICG) and Polymer Adhesives - Attachment of Fluorescence Clip and Adhesives
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Lee Ha-Eun
Kim Hong-Rae
Kim Sang-Jin
Kim Kwang-Gi
Sohn Dae-Kyung
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Abstract
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Recently, fluorescence imaging system has shown great progress. Accurate tumor localization is essential for gastrointestinal surgery, especially in cases of early cancer. Sometimes bleeding and other side effects may occur in the surgery. To overcome this problem, fluorescence imaging device is used during surgery. Fluorescence imaging in the near-infrared (NIR) spectrum (600- 900 nm) has been observed to have great potential for the noninvasive detection of disease sites in vivo . We developed a fluorescence clip which a transparent polymer matrix containing highly bright NIR fluorochromes is coated onto. Indocyanine green (ICG) is rapidly bound to serum proteins and photochemically stabilized. The maximum absorption wavelength of the aqueous solution 760 nm rapidly increases to 840 nm. Using IR spectrometer, it was confirmed that there is a change in bond of the silicone that was different from that of latex. ICG with polar solvents (Ethanol, Dimethyl sulfoxide, Water) express fluorescence but it does not with nonpolar solvents (hexane, toluene, dichloromethane) not emit a fluorescence. We should find adhesives that include polarities and react well with ICG. Polyurethane and epoxy that include polar structures are expected to express fluorescence well. Using Spectroscopy, fluorescence was observed for both polyurethane and epoxy. Although epoxy was limited in emitting fluorescence since it disappeared and stiffened, Polyurethane was active in emitting fluorescence. Fluorescence is better expressed in Polyurethane than latex and unidus rubber. The adhesive force for Polyurethane is strong, which makes it suitable for making fluorescent clips. Coated clip fluorescence of polyurethane with ICG is well expressed, the adhesion is also strong, is suitable for use in fluorescent clips. Polyurethane is difficult to manufacture because it swells up while it stiffens. We should find Polyurethane that is harmless in vivo and deforms less. We can also try to look for another adhesive or determine an ideal condition that makes the process of coating the clip easier.
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KEYWORD
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Indocyanine green (ICG), Fluorescent clip, Polar solvent, Polymer, Fluorescent guided surgery
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